The Impact of Air Pollution on Intestinal Microbiome of Asthmatic Children: A Panel Study
Joint Authors
Zhang, Bei
Zheng, Ping
Zhang, Kexing
Lv, Xifang
Wang, Qiang
Bai, Xuetao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Air pollution could impact on the alteration of intestinal microbiome.
Maturation of intestinal microbiome in early life played an important role in the development of allergic diseases, including asthma.
Recent studies presented an increase in the evidence of association between the shift of gut microbiota and asthma.
This article is aimed at exploring whether the alteration in the intestinal microbiome triggered by a short wave of air pollution could influence the colonization of bacteria that have been related to the immunological mechanisms of the asthma attack.
The impact of air pollution on intestinal microbiome was assessed by longitudinal comparison.
Fecal samples were collected twice for twenty-one children in clean and smog days, respectively, including eleven asthmatic children and ten healthy children.
Intestinal bacteria were discriminated by using the method of 16S rRNA gene sequence.
The results showed that the composition of intestinal microbiome changed between clean and smog days among all children (PERMANOVA, P=0.03).
During smog days, Bifidobacteriaceae, Erysipelotrichaceae, and Clostridium sensu stricto 1 decreased, and Streptococcaceae, Porphyromonadaceae, Rikenellaceae, Bacteroidales S24-7 group, and Bacteroides increased in asthmatic children (Wilcoxon test, P<0.05), while Fusicatenibacter decreased and Rikenellaceae and Terrisporobacter increased in healthy children (Wilcoxon test, P<0.05).
After controlling for food consumption, the relative abundance of some bacteria belonging to Firmicutes negatively associated with concentration of PM2.5, PM10, NO2, and SO2 (multiple linear regression, P<0.05).
This study demonstrated that short wave of air pollution had an impact on the intestinal microbiome of asthmatic children.
Intestinal bacteria, which have been related to immunological mechanisms of asthma attack, were also found to be associated with air pollution.
This finding suggested that a short wave of air pollution may trigger asthma by impacting on intestinal bacteria.
American Psychological Association (APA)
Zheng, Ping& Zhang, Bei& Zhang, Kexing& Lv, Xifang& Wang, Qiang& Bai, Xuetao. 2020. The Impact of Air Pollution on Intestinal Microbiome of Asthmatic Children: A Panel Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134926
Modern Language Association (MLA)
Zheng, Ping…[et al.]. The Impact of Air Pollution on Intestinal Microbiome of Asthmatic Children: A Panel Study. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134926
American Medical Association (AMA)
Zheng, Ping& Zhang, Bei& Zhang, Kexing& Lv, Xifang& Wang, Qiang& Bai, Xuetao. The Impact of Air Pollution on Intestinal Microbiome of Asthmatic Children: A Panel Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134926