Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKTmTOR Signal Pathway
Joint Authors
Wang, Zengjun
Miao, Chenkui
Li, Pu
Liang, Chao
Shao, Pengfei
Li, Jie
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that in non-CRPC cells.
Silencing CAPN2 expression could inhibit DU145 and PC3 cells proliferation by cell cycle arrest at G1 phase.
Knockdown of CPAN2 level suppressed the migration and invasion capacity of CRPC cells by reducing matrix metalloproteinase-2 (MMP-2) and MMP-9 activation, as well as repressing the phosphorylation protein expression of AKT and mTOR.
In addition, we found that the expression of CAPN2 was elevated in Pca tissues than that in normal control tissues.
Therefore, we showed the important roles of CAPN2 in the development and progression in CRPC cells, suggesting a new therapeutic intervention for treating castration-resistant prostate cancer patients.
American Psychological Association (APA)
Li, Pu& Miao, Chenkui& Liang, Chao& Shao, Pengfei& Wang, Zengjun& Li, Jie. 2017. Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKTmTOR Signal Pathway. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134945
Modern Language Association (MLA)
Li, Pu…[et al.]. Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKTmTOR Signal Pathway. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134945
American Medical Association (AMA)
Li, Pu& Miao, Chenkui& Liang, Chao& Shao, Pengfei& Wang, Zengjun& Li, Jie. Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKTmTOR Signal Pathway. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134945