Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity
Joint Authors
Vitagliano, Luigi
Esposito, Luciana
Balasco, Nicole
Thind, Amarinder Singh
Guarracino, Mario Rosario
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Proteins frequently assume complex three-dimensional structures characterized by marginal thermodynamic stabilities.
In this scenario, deciphering the folding code of these molecular giants with clay feet is a cumbersome task.
Studies performed in last years have shown that the interplay between backbone geometry and local conformation has an important impact on protein structures.
Although the variability of several geometrical parameters of protein backbone has been established, the role of the structural context in determining these effects has been hitherto limited to the valence bond angle τ (NCαC).
We here investigated the impact of different factors on the observed variability of backbone geometry and peptide bond planarity.
These analyses corroborate the notion that the local conformation expressed in terms of (ϕ,ψ) dihedrals plays a predominant role in dictating the variability of these parameters.
The impact of secondary structure is limited to bond angles which involve atoms that are usually engaged in H-bonds and, therefore, more susceptible to the structural context.
Present data also show that the nature of the side chain has a significant impact on angles such as NCαCβ and CβCαC.
In conclusion, our analyses strongly support the use of variability of protein backbone geometry in structure refinement, validation, and prediction.
American Psychological Association (APA)
Balasco, Nicole& Esposito, Luciana& Thind, Amarinder Singh& Guarracino, Mario Rosario& Vitagliano, Luigi. 2017. Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134986
Modern Language Association (MLA)
Balasco, Nicole…[et al.]. Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134986
American Medical Association (AMA)
Balasco, Nicole& Esposito, Luciana& Thind, Amarinder Singh& Guarracino, Mario Rosario& Vitagliano, Luigi. Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134986