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Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression
Joint Authors
Zou, Yang
Li, Rong
Kuang, Dabin
Zuo, Meiling
Li, Wenqun
Tong, Wei
Jiang, Li
Zhou, Min
Chen, Yin
Gong, Wencheng
Liu, Lijuan
Tou, Fangfang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Galangin, a natural flavonoid product derived from the root of galangal, is emerging as a promising anticancer agent against multiple cancers.
Yet, whether it also has antitumor effects on cholangiocarcinoma (CCA) and the underlying mechanism is still unknown.
Herein, we demonstrate that galangin exhibits multiple antitumor effects on CCA cells including decreases cell viability; inhibits proliferation, migration, and invasion; and induces apoptosis.
Moreover, those phenotypic changes are associated with downregulated microRNA-21 (miR-21) expression.
To support, overexpression of miR-21 blocks galangin-mediated antisurvival and metastasis effects on CCA cells.
Mechanically, galangin increases the expression of phosphatase and tensin homolog (PTEN), a direct target of miR-21, resulting in decreased phosphorylation of AKT, a protein kinase which plays a critical role in controlling survival and apoptosis.
In contrast, overexpression of miR-21 abrogates galangin-regulated PTEN expression and AKT phosphorylation.
Taken together, these findings indicate that galangin inhibits CCA cell proliferation and metastasis and induces cell apoptosis through a miR-21-dependent manner, and galangin may provide a novel potential therapeutic adjuvant to treat CCA.
American Psychological Association (APA)
Zou, Yang& Li, Rong& Kuang, Dabin& Zuo, Meiling& Li, Wenqun& Tong, Wei…[et al.]. 2020. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135012
Modern Language Association (MLA)
Zou, Yang…[et al.]. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135012
American Medical Association (AMA)
Zou, Yang& Li, Rong& Kuang, Dabin& Zuo, Meiling& Li, Wenqun& Tong, Wei…[et al.]. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135012