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Combined Administration of Bisphosphonates, Chemotherapeutic Agents, andor Targeted Drugs Increases the Risk for Stage 3 Medication-Related Osteonecrosis of the Jaw: A 4-Year Retrospective Study
Joint Authors
Chi, Yang
Zhou, Yuqiong
Yu, Yejia
Shi, Yueqi
Li, Mengyu
Wang, Shaoyi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Patients with stage 3 medication-related osteonecrosis of the jaw (MRONJ) suffer from severe complications.
Chemotherapeutic agents and targeted drugs are considered to be associated with the development of MRONJ.
However, little is known regarding the association of those agents with stage 3 MRONJ.
The purpose of this study is to analyze the comprehensive medication history of patients with advanced-stage MRONJ (stage 2 and stage 3) and evaluate the possible risk factors for stage 3 MRONJ.
Patients and Methods.
Sixty patients with advanced-stage MRONJ were involved in this retrospective study.
Patients with developmental maxillofacial anomalies, previous radiation in the head and neck areas, and jaw bone tumors were excluded from the study.
All patients were divided into two groups by their MRONJ stage (stage 2 or stage 3).
Demographic and clinical characteristics, comprehensive medication data (bisphosphonates, chemotherapeutic agents, targeted drugs, and immunosuppressive agents), and results of serological biomarkers were recorded and compared between two groups.
Univariate and multivariate logistic regressions were performed by SPSS 25.0 for evaluating risk factors of stage 3 MRONJ.
Results.
Our results indicate that chemotherapy (adjusted OR=3.43; 95% CI: 1.03 to 11.38), targeted drugs (adjusted OR=3.69; 95% CI: 1.06 to 12.80), and maxillary lesions (adjusted OR=4.26; 95% CI: 1.19 to 15.23) increase the risk of stage 3 MRONJ.
Conclusion.
The outcome of this study justifies that chemotherapeutic agents and targeted drugs are probably risk factors for stage 3 MRONJ.
In addition, the osteonecrosis in maxilla is more easily to develop into stage 3 MRONJ.
Intense clinical observation is recommended in MRONJ patients with maxillary osteonecrosis and in those who concurrently administered bisphosphonates, chemotherapeutic agents, and/or targeted drugs.
This trial is registered with ChiCTR2000032428.
American Psychological Association (APA)
Zhou, Yuqiong& Yu, Yejia& Shi, Yueqi& Li, Mengyu& Chi, Yang& Wang, Shaoyi. 2020. Combined Administration of Bisphosphonates, Chemotherapeutic Agents, andor Targeted Drugs Increases the Risk for Stage 3 Medication-Related Osteonecrosis of the Jaw: A 4-Year Retrospective Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135015
Modern Language Association (MLA)
Zhou, Yuqiong…[et al.]. Combined Administration of Bisphosphonates, Chemotherapeutic Agents, andor Targeted Drugs Increases the Risk for Stage 3 Medication-Related Osteonecrosis of the Jaw: A 4-Year Retrospective Study. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1135015
American Medical Association (AMA)
Zhou, Yuqiong& Yu, Yejia& Shi, Yueqi& Li, Mengyu& Chi, Yang& Wang, Shaoyi. Combined Administration of Bisphosphonates, Chemotherapeutic Agents, andor Targeted Drugs Increases the Risk for Stage 3 Medication-Related Osteonecrosis of the Jaw: A 4-Year Retrospective Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135015