Profiles of Immune Infiltration and Prognostic Immunoscore in Lung Adenocarcinoma
Joint Authors
Li, Yanyan
Tao, Liping
Cai, Weiyang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Lung tissue is abundant with immune cells that form a powerful first defense against exotic particles and microbes.
The malignant phenotype of lung adenocarcinoma (LUAD) is defined not only by intrinsic tumor cells but also by tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment.
Understanding more about the immune microenvironment of LUAD could function in sorting out patients more likely with high risk and benefit from immunotherapy.
Twenty-two types of TIICs were estimated based on large public LUAD cohorts from the TCGA and GEO datasets using the CIBERSORT algorithm.
Then principal component analysis (PCA), meta-analysis, and single-sample gene set enrichment analysis (ssGSEA) were used to measure and evaluate the specific immune responses and relative mechanisms.
Moreover, an immunoscore model based on the percent of immune cells was constructed via the univariate and multivariate Cox regression models, which provided an in-depth overview of the LUAD immune microenvironment and shed light on the immune regulatory mechanism.
The differential expression genes (DEGs) were acquired based on the immunoscore model, and prognostic immune-related genes were further identified.
GSEA and the protein–protein interaction network (PPI) further revealed that these genes were mostly enriched in many immune-related biological processes.
It is hoped that this immune landscape could provide a more accurate understanding for LUAD development and tumor immune therapy.
American Psychological Association (APA)
Li, Yanyan& Tao, Liping& Cai, Weiyang. 2020. Profiles of Immune Infiltration and Prognostic Immunoscore in Lung Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1135035
Modern Language Association (MLA)
Li, Yanyan…[et al.]. Profiles of Immune Infiltration and Prognostic Immunoscore in Lung Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1135035
American Medical Association (AMA)
Li, Yanyan& Tao, Liping& Cai, Weiyang. Profiles of Immune Infiltration and Prognostic Immunoscore in Lung Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1135035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135035