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Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients
Joint Authors
Gallina, Pasquale
Mrzilkova, Jana
Bartoš, A.
Lagutina, A.
Wurst, Z.
Rai, T.
Kieslich, K.
Riedlová, J.
Ibrahim, I.
Tintěra, J.
Zach, Petr
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Measurement of an- hippocampal area or volume is useful in clinical practice as a supportive aid for diagnosis of Alzheimer’s disease.
Since it is time-consuming and not simple, it is not being used very often.
We present a simplified protocol for hippocampal atrophy evaluation based on a single optimal slice in Alzheimer’s disease.
Methods.
We defined a single optimal slice for hippocampal measurement on brain magnetic resonance imaging (MRI) at the plane where the amygdala disappears and only the hippocampus is present.
We compared an absolute area and volume of the hippocampus on this optimal slice between 40 patients with Alzheimer disease and 40 age-, education- and gender-mateched elderly controls.
Furthermore, we compared these results with those relative to the size of the brain or the skull: the area of the optimal slice normalized to the area of the brain at anterior commissure and the volume of the hippocampus normalized to the total intracranial volume.
Results.
Hippocampal areas on the single optimal slice and hippocampal volumes on the left and right in the control group were significantly higher than those in the AD group.
Normalized hippocampal areas and volumes on the left and right in the control group were significantly higher compared to the AD group.
Absolute hippocampal areas and volumes did not significantly differ from corresponding normalized hippocampal areas as well as normalized hippocampal volumes using comparisons of areas under the receiver operating characteristic curves.
Conclusion.
The hippocampal area on the well-defined optimal slice of brain MRI can reliably substitute a complicated measurement of the hippocampal volume.
Surprisingly, brain or skull normalization of these variables does not add any incremental differentiation between Alzheimer disease patients and controls or give better results.
American Psychological Association (APA)
Zach, Petr& Bartoš, A.& Lagutina, A.& Wurst, Z.& Gallina, Pasquale& Rai, T.…[et al.]. 2020. Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135074
Modern Language Association (MLA)
Zach, Petr…[et al.]. Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1135074
American Medical Association (AMA)
Zach, Petr& Bartoš, A.& Lagutina, A.& Wurst, Z.& Gallina, Pasquale& Rai, T.…[et al.]. Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135074