Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs
Joint Authors
Xu, Yan
Xu, Ling
Chen, Cunte
Zhang, Yikai
Zeng, Chengwu
Jin, Zhenyi
Chen, Shaohua
Li, Bo
Zha, Xianfeng
Yin, Zhinan
Li, Yangqiu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
T cell immunity plays a central role in the body’s defense system, including maintaining homeostasis and preventing tumorigenesis and viral infection.
Immune system functions degenerate with age, leading to immune senescence.
Physiologically, immune senescence is characterized by a decrease in T cell receptor diversity, naive T cell deficiency, and alterations in T cell immune-related miRNAs.
However, little is known about the characteristics of T cell immunosenescence in Chinese individuals.
Results.
A significant decrease in the miR-17, miR-92a, and miR-181a levels in PBMCs was detected with age.
The miR-92a and miR-181a levels were upregulated in CBMCs when comparing healthy individuals to group I (0~9 years), whereas miR-17 was downregulated.
The sjTREC level in PBMCs was negatively correlated with age, and a sharp decrease in sjTRECs was found between groups I and II (10~19 years).
Twenty-four TCR Vβ subfamilies could be detected in most samples, and most displayed polyclonality, while skewed expression of the Vβ subfamilies as well as an increased oligoclonal tendency was found with age.
Similarly, the frequencies of the TCR Vγ and Vδ subfamilies decreased with age, and the alteration in clonality appeared to be stable at different ages.
Conclusion.
We made the novel observation of T cell immunosenescence with age in Chinese individuals, which may provide information for immune targets to enhance the T cell immune response in immunotherapy settings for elderly patients.
American Psychological Association (APA)
Xu, Yan& Xu, Ling& Chen, Cunte& Zhang, Yikai& Zeng, Chengwu& Jin, Zhenyi…[et al.]. 2020. Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135087
Modern Language Association (MLA)
Xu, Yan…[et al.]. Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135087
American Medical Association (AMA)
Xu, Yan& Xu, Ling& Chen, Cunte& Zhang, Yikai& Zeng, Chengwu& Jin, Zhenyi…[et al.]. Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135087