Predicting Factors for Allogeneic Blood Transfusion and Excessive Postoperative Blood Loss after Single Low-Dosage Intra-Articular Tranexamic Acid Application in Total Knee Replacement
Joint Authors
Sa-ngasoongsong, Paphon
Chanplakorn, Pongsthorn
Wongsak, Siwadol
Kawinwonggowit, Viroj
Kulachote, Noratep
Woratanarat, Patarawan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Recently, intra-articular tranexamic acid (IA-TXA) application has become a popular method for perioperative blood loss (PBL) reduction in total knee replacement (TKR).
Nevertheless, through our knowledge, no previous studies had shown the correlation perioperative factors and the risk of excessive PBL or need of blood transfusion (BT) after IA-TXA.
Materials and Methods.
A retrospective study was conducted in patients underwent 299 primary TKRs, using IA-TXA, during 2-year period (2013-2014).
Patient’s characteristic and perioperative data were reviewed and collected.
PBL was measured as total hemoglobin loss (THL), estimated total blood loss (ETBL), and drainage volume per kg (DV/kg).
Excessive PBL was defined as PBL that exceeded 90th percentile.
Results.
From multivariate analysis, low preoperative hemoglobin (Hb) level and body mass index (BMI) were the significant predictors of postoperative BT (p<0.0001 and 0.003, resp.).
Excessive THL significant associated with preoperative Hb (p<0.0001).
Excessive ETBL significantly associated with preoperative Hb, height, preoperative range-of-motion, and creatinine clearance (p<0.05 all).
Low BMI and large prosthesis size were the significant predictors of excessive DV/kg (p=0.0001 and 0.002, resp.).
Conclusions.
Low preoperative Hb and BMI were the significant risks of postoperative transfusion after TKR with IA-TXA.
Moreover, multiple perioperative factors could result in higher PBL.
American Psychological Association (APA)
Sa-ngasoongsong, Paphon& Wongsak, Siwadol& Kulachote, Noratep& Chanplakorn, Pongsthorn& Woratanarat, Patarawan& Kawinwonggowit, Viroj. 2017. Predicting Factors for Allogeneic Blood Transfusion and Excessive Postoperative Blood Loss after Single Low-Dosage Intra-Articular Tranexamic Acid Application in Total Knee Replacement. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135088
Modern Language Association (MLA)
Sa-ngasoongsong, Paphon…[et al.]. Predicting Factors for Allogeneic Blood Transfusion and Excessive Postoperative Blood Loss after Single Low-Dosage Intra-Articular Tranexamic Acid Application in Total Knee Replacement. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135088
American Medical Association (AMA)
Sa-ngasoongsong, Paphon& Wongsak, Siwadol& Kulachote, Noratep& Chanplakorn, Pongsthorn& Woratanarat, Patarawan& Kawinwonggowit, Viroj. Predicting Factors for Allogeneic Blood Transfusion and Excessive Postoperative Blood Loss after Single Low-Dosage Intra-Articular Tranexamic Acid Application in Total Knee Replacement. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135088