Low-Frequency Ultrasound Enhances Bactericidal Activity of Antimicrobial Agents against Klebsiella pneumoniae Biofilm
Joint Authors
Cai, Yun
Wang, Jin
Weng, Chun-xiao
Liu, Xu
Wang, Rui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Klebsiella pneumoniae biofilms on inserted devices have been proposed as one of the important factors for hospital-acquired infections, which cause increased resistance to currently used antibiotics.
Therefore, it is urgently necessary to develop new treatments with more efficient bacterial clearance.
In the present study, we aimed at investigating whether low-frequency ultrasound (LFU) could enhance the bactericidal activity of antimicrobial agents (meropenem (MEM), tigecycline (TGC), fosfomycin (FOM), amikacin (AMK), and colistin (COL)) against K.
pneumoniae biofilm infection.
K.
pneumoniae biofilm was cultivated on the catheter in vitro.
Synergistic effects were observed in groups of single ultrasound (S-LFU, 5 min) or multiple ultrasound (M-LFU, 5 min every 8 h (q8h)) in combination with MEM, TGC, and FOM.
However, AMK and COL did not show the synergistic effect with either S-LFU or M-LFU.
S-LFU in combination with FOM only significantly decreased bacterial counts right after ultrasound, while M-LFU could prolong the synergistic effect until 24 h.
The results showed that LFU in combination with antimicrobial agents had a synergistic effect on K.
pneumoniae biofilm, and M-LFU might extend the time of synergistic effect compared with S-LFU.
American Psychological Association (APA)
Liu, Xu& Wang, Jin& Weng, Chun-xiao& Wang, Rui& Cai, Yun. 2020. Low-Frequency Ultrasound Enhances Bactericidal Activity of Antimicrobial Agents against Klebsiella pneumoniae Biofilm. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135092
Modern Language Association (MLA)
Liu, Xu…[et al.]. Low-Frequency Ultrasound Enhances Bactericidal Activity of Antimicrobial Agents against Klebsiella pneumoniae Biofilm. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1135092
American Medical Association (AMA)
Liu, Xu& Wang, Jin& Weng, Chun-xiao& Wang, Rui& Cai, Yun. Low-Frequency Ultrasound Enhances Bactericidal Activity of Antimicrobial Agents against Klebsiella pneumoniae Biofilm. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135092