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Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Most tumor suppressor genes are commonly inactivated in the development of colorectal cancer (CRC).
The activation of tumor suppressor genes may be beneficial to suppress the development and metastasis of CRC.
This study analyzed genes expression and methylation levels in different stages of CRC.
Genes with downregulated mRNA expression and upregulated methylation level in advanced CRC were screened as the potential tumor suppressor genes.
After comparing the methylation level of screened genes, we found that MBD1 gene had downregulated mRNA expression and upregulated methylation levels in advanced CRC and continuously upregulated methylation level in the progression of CRC.
Enrichment analysis revealed that genes expression in accordance with the elevated expression of MBD1 mainly located on chromosomes 17p13 and 17p12 and 8 tumor suppressor genes located on chromosome 17p13.
Further enrichment analysis of transcription factor binding site identified that SP1 binding site had higher enrichment and could bind with MBD1.
In conclusion, MBD1 may be a tumor suppressor gene in advanced CRC and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1.
American Psychological Association (APA)
Qi, Lu& Ding, Yanqing. 2017. Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135402
Modern Language Association (MLA)
Qi, Lu& Ding, Yanqing. Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135402
American Medical Association (AMA)
Qi, Lu& Ding, Yanqing. Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135402