Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications
Joint Authors
Zhao, Jungang
Bao, Wenming
Cai, Weiyang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Intrinsic cancer cells and the tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment define the malignant phenotype of lung squamous cell carcinoma (LUSC).
Understanding more about the immune microenvironment of LUSC enables the selection of high-risk patients who would derive benefit from immunotherapy.
Based on large public LUSC cohorts obtained from TCGA and GEO datasets, 22 types of infiltrating immune cell subgroups were evaluated by CIBERSORT.
Meta-analysis, principal component analysis (PCA), single-sample gene set enrichment analysis (ssGSEA), and hierarchical clustering analysis were used to evaluate specific immune responses of LUSC.
The distribution of TIICs of LUSC was entirely different from normal.
TIIC subpopulations were also found to be closely associated with clinical features and molecular subtypes.
Unsupervised clustering analysis revealed that three distinct TIIC subgroups existed with different survival patterns.
TIICs are extensively implicated in the pathogenesis and development of LUSC.
Characterizing the composition of TIICs influences the metabolism, pathological stage, and survival of tumor patients.
It is hoped that this immune landscape could provide a more accurate understanding of the development and immunotherapy of LUSC.
American Psychological Association (APA)
Zhao, Jungang& Bao, Wenming& Cai, Weiyang. 2020. Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications. BioMed Research International،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1135418
Modern Language Association (MLA)
Zhao, Jungang…[et al.]. Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications. BioMed Research International No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1135418
American Medical Association (AMA)
Zhao, Jungang& Bao, Wenming& Cai, Weiyang. Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1135418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135418