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The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm
Joint Authors
Strzyżewski, Krzysztof Wojciech
Kasprzak, Magdalena
Krasiński, Zbigniew
Gryszczyńska, Bogna
Budzyń, Magdalena
Formanowicz, Dorota
Iskra, Maria
Majewski, Wacław
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury.
Materials and Methods.
Forty-one patients with AAA were involved and divided into subgroups based on different criteria.
Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA).
The results were compared with those obtained in 30 healthy age- and sex-matched volunteers.
Results.
The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97–2.82) ng/mL versus 3.93 (2.43–9.20) ng/mL, P < 0.001].
An elevated sTM associated significantly with increased triglycerides (TAG) [P = 0.022], cholesterol [P = 0.029], hsCRP [P = 0.031], and advanced glycation end products (AGEs) [P = 0.033].
Conclusions.
The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis.
The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.
American Psychological Association (APA)
Budzyń, Magdalena& Gryszczyńska, Bogna& Majewski, Wacław& Krasiński, Zbigniew& Kasprzak, Magdalena& Formanowicz, Dorota…[et al.]. 2017. The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135419
Modern Language Association (MLA)
Budzyń, Magdalena…[et al.]. The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135419
American Medical Association (AMA)
Budzyń, Magdalena& Gryszczyńska, Bogna& Majewski, Wacław& Krasiński, Zbigniew& Kasprzak, Magdalena& Formanowicz, Dorota…[et al.]. The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135419