Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants
Joint Authors
Van Huffel, Sabine
Hendrikx, Dries
Thewissen, Liesbeth
Smits, Anne
Naulaers, Gunnar
Caicedo, Alexander
Allegaert, Karel
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Graphs can be used to describe a great variety of real-world situations and have therefore been used extensively in different fields.
In the present analysis, we use graphs to study the interaction between cerebral function, brain hemodynamics, and systemic variables in premature neonates.
We used data from a propofol dose-finding and pharmacodynamics study as a model in order to evaluate the performance of the graph measures to monitor signal interactions.
Concomitant measurements of heart rate, mean arterial blood pressure, arterial oxygen saturation, regional cerebral oxygen saturation—measured by means of near-infrared spectroscopy—and electroencephalography were performed in 22 neonates undergoing INSURE (intubation, surfactant administration, and extubation).
The graphs used to study the interaction between these signal modalities were constructed using the RBF kernel.
Results indicate that propofol induces a decrease in the signal interaction up to 90 minutes after propofol administration, which is consistent with clinical observations published previously.
The clinical recovery phase is mainly determined by the EEG dynamics, which were observed to recover much slower compared to the other modalities.
In addition, we found a more pronounced loss in cerebral-systemic interactions with increasing propofol dose.
American Psychological Association (APA)
Hendrikx, Dries& Thewissen, Liesbeth& Smits, Anne& Naulaers, Gunnar& Allegaert, Karel& Van Huffel, Sabine…[et al.]. 2018. Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants. Complexity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1135420
Modern Language Association (MLA)
Hendrikx, Dries…[et al.]. Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants. Complexity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1135420
American Medical Association (AMA)
Hendrikx, Dries& Thewissen, Liesbeth& Smits, Anne& Naulaers, Gunnar& Allegaert, Karel& Van Huffel, Sabine…[et al.]. Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants. Complexity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1135420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135420