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Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort
Joint Authors
Pecks, Ulrich
Göpel, Wolfgang
Norda, Stephen
Rausch, Tanja K.
Hütten, Matthias
Schulz, Sören
Orlikowsky, Thorsten W.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles.
Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism.
Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect.
We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life.
Methods.
A cohort of 4885 preterm infants (≥22+0 and <32+0 weeks of gestation and birth weight below 1500 g) from the GNN study cohort was analyzed.
Neonates were categorized into subgroups of <3rd, 3rd–10th, and >10th birth weight percentile.
Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan® SNP genotyping assays.
The proportional odds model was used to assess data.
Results.
No association was found between genotype and birth weight percentiles in each of the subgroups.
Conclusion.
ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.
American Psychological Association (APA)
Norda, Stephen& Rausch, Tanja K.& Orlikowsky, Thorsten W.& Hütten, Matthias& Schulz, Sören& Göpel, Wolfgang…[et al.]. 2017. Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135452
Modern Language Association (MLA)
Norda, Stephen…[et al.]. Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1135452
American Medical Association (AMA)
Norda, Stephen& Rausch, Tanja K.& Orlikowsky, Thorsten W.& Hütten, Matthias& Schulz, Sören& Göpel, Wolfgang…[et al.]. Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135452