Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer
Joint Authors
Liu, Kaisheng
Lai, Minshan
Wang, Shaoxiang
Zheng, Kai
Xie, Shouxia
Wang, Xiao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Colon cancer is the third most common cancer, with a high incidence and mortality.
Construction of a specific and sensitive prediction model for prognosis is urgently needed.
In this study, profiles of patients with colon cancer with clinical and gene expression data were downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA).
CXC chemokines in patients with colon cancer were investigated by differential expression gene analysis, overall survival analysis, receiver operating characteristic analysis, gene set enrichment analysis (GSEA), and weighted gene coexpression network analysis.
CXCL1, CXCL2, CXCL3, and CXCL11 were upregulated in patients with colon cancer and significantly correlated with prognosis.
The area under curve (AUC) of the multigene forecast model of CXCL1, CXCL11, CXCL2, and CXCL3 was 0.705 in the GSE41258 dataset and 0.624 in TCGA.
The prediction model was constructed using the risk score of the multigene model and three clinicopathological risk factors and exhibited 92.6% and 91.8% accuracy in predicting 3-year and 5-year overall survival of patients with colon cancer, respectively.
In addition, by GSEA, expression of CXCL1, CXCL11, CXCL2, and CXCL3 was correlated with several signaling pathways, including NOD-like receptor, oxidative phosphorylation, mTORC1, interferon-gamma response, and IL6/JAK/STAT3 pathways.
Patients with colon cancer will benefit from this prediction model for prognosis, and this will pave the way to improve the survival rate and optimize treatment for colon cancer.
American Psychological Association (APA)
Liu, Kaisheng& Lai, Minshan& Wang, Shaoxiang& Zheng, Kai& Xie, Shouxia& Wang, Xiao. 2020. Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1135504
Modern Language Association (MLA)
Liu, Kaisheng…[et al.]. Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1135504
American Medical Association (AMA)
Liu, Kaisheng& Lai, Minshan& Wang, Shaoxiang& Zheng, Kai& Xie, Shouxia& Wang, Xiao. Construction of a CXC Chemokine-Based Prediction Model for the Prognosis of Colon Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1135504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135504