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Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology
Joint Authors
Liu, Na
Zhang, Miaomiao
Xie, Fuda
Xie, Mingxiang
Yang, Yibing
Xiao, Wei
Gu, Jiangyong
Xu, Xiaojie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Reduning Injection (RDNI) is a traditional Chinese medicine formula indicated for the treatment of inflammatory diseases.
However, the molecular mechanism of RDNI is unclear.
The information of RDNI ingredients was collected from previous studies.
Targets of them were obtained by data mining and molecular docking.
The information of targets and related pathways was collected in UniProt and KEGG.
Networks were constructed and analyzed by Cytoscape to identify key compounds, targets, and pathways.
Data mining and molecular docking identified 11 compounds, 84 targets, and 201 pathways that are related to the anti-inflammatory activity of RDNI.
Network analysis identified two key compounds (caffeic acid and ferulic acid), five key targets (Bcl-2, eNOS, PTGS2, PPARA, and MMPs), and four key pathways (estrogen signaling pathway, PI3K-AKT signaling pathway, cGMP-PKG signaling pathway, and calcium signaling pathway) which would play critical roles in the treatment of inflammatory diseases by RDNI.
The cross-talks among pathways provided a deeper understanding of anti-inflammatory effect of RDNI.
RDNI is capable of regulating multiple biological processes and treating inflammation at a systems level.
Network pharmacology is a practical approach to explore the therapeutic mechanism of TCM for complex disease.
American Psychological Association (APA)
Xie, Fuda& Xie, Mingxiang& Yang, Yibing& Zhang, Miaomiao& Xu, Xiaojie& Liu, Na…[et al.]. 2020. Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135523
Modern Language Association (MLA)
Xie, Fuda…[et al.]. Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135523
American Medical Association (AMA)
Xie, Fuda& Xie, Mingxiang& Yang, Yibing& Zhang, Miaomiao& Xu, Xiaojie& Liu, Na…[et al.]. Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135523