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Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome
Joint Authors
Guillen Nieto, Gerardo E.
Fernández-Montequín, José
Valdés-Pérez, Calixto
Savigne-Gutiérrez, William
Mendoza-Marí, Yssel
García-Ojalvo, Ariana
Falcón‐Cama, Viviana
Fernández-Mayola, Maday
Pérez-Saad, Héctor
Pimentel-Vázquez, Eulogio
Urquiza-Rodríguez, Aleida
Kulikovsky, Moshe
Berlanga-Acosta, Jorge
García del Barco Herrera, Diana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing.
EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and endothelial cells via a tyrosine kinase membrane receptor.
Compelling evidences from the 90s documented that, for EGF, locally prolonged bioavailability and hourly interaction with the receptor were necessary for a successful tissue response.
Eventually, the enthusiasm on the clinical use of EGF to steer the healing process was wiped out as the topical route to deliver proteins started to be questioned.
The simultaneous in vivo experiments, emphasizing the impact of the parenterally administered EGF on epithelial and nonepithelial organs in terms of mitogenesis and cytoprotection, rendered the theoretical fundamentals for the injectable use of EGF and shaped the hypothesis that locally infiltrating the diabetic ulcers would lead to an effective healing.
Although the diabetic chronic wounds microenvironment is hostile for local GFs bioavailability, EGF local infiltration circumvented the limitations of its topical application, thus expanding its therapeutic prospect.
Our clinical pharmacovigilance and basic studies attest the significance of the GF local infiltration for chronic wounds healing.
American Psychological Association (APA)
Berlanga-Acosta, Jorge& Fernández-Montequín, José& Valdés-Pérez, Calixto& Savigne-Gutiérrez, William& Mendoza-Marí, Yssel& García-Ojalvo, Ariana…[et al.]. 2017. Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135525
Modern Language Association (MLA)
Berlanga-Acosta, Jorge…[et al.]. Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135525
American Medical Association (AMA)
Berlanga-Acosta, Jorge& Fernández-Montequín, José& Valdés-Pérez, Calixto& Savigne-Gutiérrez, William& Mendoza-Marí, Yssel& García-Ojalvo, Ariana…[et al.]. Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135525