Identification of 6 Hub Proteins and Protein Risk Signature of Colorectal Cancer
Joint Authors
Xu, Hao
Liu, Cheng
Zhu, Jing
Liu, Yucun
Zhang, Yuyang
Yue, Taohua
Huang, Zhihao
Guo, Shihao
Wang, Pengyuan
Chen, Shanwen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Colorectal cancer (CRC) is the second most common cause of cancer death in the United States and the third most common cancer globally.
The incidence of CRC tends to be younger, and we urgently need a reliable prognostic assessment strategy.
Methods.
Protein expression profile and clinical information of 390 CRC patients/samples were downloaded from the TCPA and TCGA database, respectively.
The Kaplan-Meier, Cox regression, and Pearson correlation analysis were applied in this study.
Results.
Based on the TCPA and TCGA database, we screened 6 hub proteins and first constructed protein risk signature, all of which were significantly associated with CRC patients’ overall survival (OS).
The risk score was an independent prognostic factor and significantly related with the size of the tumor in situ (T).
6 hub proteins were differentially expressed in cancer and normal tissues and in different CRC stages, which were validated at the ONCOMINE database.
Next, 40 coexpressed proteins of 6 hub proteins were extracted from the TCPA database.
In the protein-protein interaction (PPI) network, HER1, HER2, and CTNNB1 were at the center.
Function enrichment analysis illustrated that 46 proteins were mainly involved in the EGFR (HER1) tyrosine kinase inhibitor resistance pathway.
Conclusion.
Studies indicated that 6 hub proteins might be considered as new targets for CRC therapies, and the protein risk signature can be used to predict the OS of CRC patients.
American Psychological Association (APA)
Yue, Taohua& Liu, Cheng& Zhu, Jing& Huang, Zhihao& Wang, Pengyuan& Chen, Shanwen…[et al.]. 2020. Identification of 6 Hub Proteins and Protein Risk Signature of Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1135526
Modern Language Association (MLA)
Wang, Pengyuan…[et al.]. Identification of 6 Hub Proteins and Protein Risk Signature of Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1135526
American Medical Association (AMA)
Yue, Taohua& Liu, Cheng& Zhu, Jing& Huang, Zhihao& Wang, Pengyuan& Chen, Shanwen…[et al.]. Identification of 6 Hub Proteins and Protein Risk Signature of Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1135526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135526