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Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis
Joint Authors
Liu, Juan
Hu, Bin
Wang, Yang
Deng, Zhi-Feng
Zhou, Xiang
Li, Qing
Zhou, Shu-Min
Hu, Guo-Wen
Niu, Xin
Guo, Shang-Chun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acetylation or deacetylation of chromatin proteins and transcription factors is part of a complex signaling system that is involved in the control of neurological disorders.
Recent studies have demonstrated that histone deacetylases (HDACs) exert protective effects in attenuating neuronal injury after ischemic insults.
Class IIa HDAC4 is highly expressed in the brain, and neuronal activity depends on the nucleocytoplasmic shuttling of HDAC4.
However, little is known about HDAC4 and its roles in ischemic stroke.
In this study, we report that phosphorylation of HDAC4 was remarkably upregulated after stroke and blockade of HDAC4 phosphorylation with GÖ6976 repressed stroke-induced angiogenesis.
Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and suppression of HDAC4 phosphorylation inhibited the tube formation and migration of endothelial cells in vitro.
Furthermore, in addition to the inhibition of angiogenesis, blockade of HDAC4 phosphorylation suppressed the expression of genes downstream of HIF-VEGF signaling in vitro and in vivo.
These data indicate that phosphorylated HDAC4 may serve as an important regulator in stroke-induced angiogenesis.
The protective mechanism of phosphorylated HDAC4 is associated with HIF-VEGF signaling, implicating a novel therapeutic target in stroke.
American Psychological Association (APA)
Liu, Juan& Zhou, Xiang& Li, Qing& Zhou, Shu-Min& Hu, Bin& Hu, Guo-Wen…[et al.]. 2017. Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135568
Modern Language Association (MLA)
Liu, Juan…[et al.]. Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1135568
American Medical Association (AMA)
Liu, Juan& Zhou, Xiang& Li, Qing& Zhou, Shu-Min& Hu, Bin& Hu, Guo-Wen…[et al.]. Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135568