Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model
Joint Authors
Kuyama, Kayo
Min, Seiko
Kim, Taewan
Kim, Oksu
Goncalo, Carames
Utsunomiya, Tadahiko
Matsumoto, Takashi
Angelov, Nikola
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model.
Materials and Methods.
The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM).
The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group).
Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses.
Outcomes were compared between groups.
Results.
3D imaging using cone beam computed tomography (CBCT) revealed that sites treated with ABBM-C and CM functionalized with anti-BMP-2 mAb exhibited significantly more remaining bone width near the alveolar crest, as well as buccal bone height, compared with control groups.
Histologic and histomorphometric analyses demonstrated that in anti-BMP-2 mAb-treated sites, total tissue volume was significantly higher in the coronal part of the alveolar bone crest compared with control sites.
In anti-BMP-2 mAb-treated sites, bone formation was observed under the barrier membrane.
Conclusion.
Functionalization of the ABBM-C scaffold and CM appeared to have led to bone formation within healing alveolar bone sockets.
American Psychological Association (APA)
Min, Seiko& Kim, Taewan& Kim, Oksu& Goncalo, Carames& Utsunomiya, Tadahiko& Matsumoto, Takashi…[et al.]. 2020. Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1135575
Modern Language Association (MLA)
Min, Seiko…[et al.]. Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1135575
American Medical Association (AMA)
Min, Seiko& Kim, Taewan& Kim, Oksu& Goncalo, Carames& Utsunomiya, Tadahiko& Matsumoto, Takashi…[et al.]. Functionalized Scaffold and Barrier Membrane with Anti-BMP-2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1135575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135575