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The Diagnostic Roles of Cytokines in Hepatobiliary Cancers
Joint Authors
Koca, Yavuz Savas
Barut, İbrahim
Bulbul, Mahmut
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
The aim of this study was to investigate the role of several cytokines including IL-2, IL-6, IL-8, IL-10, and TNF-α in the diagnosis of HPB cancers.
Materials and Methods.
The prospective study was performed between October 2007 and September 2014.
The study included 226 patients who were divided into 5 groups depending on their postoperative and histopathologic diagnosis: Control group included 30 healthy volunteers.
Hepatocellular cancer (HCC) group included 24 patients diagnosed with HCC.
Gallbladder cancer (GBC) group included 36 patients diagnosed with GBC.
Cholangiocellular carcinoma group included 64 patients diagnosed with cholangiocellular carcinoma.
Pancreatic cancer group included 72 patients diagnosed with pancreatic cancer.
Serum levels of IL-2, IL-6, IL-8, IL-10, and TNF-α were measured using an enzyme-linked immunosorbent assay kit in accordance with the guidelines of the producer.
Results.
Serum TNF-α concentration was significantly higher in the cholangiocellular carcinoma and pancreatic cancer groups compared to other groups.
IL-6 and IL-10 were significantly increased in both the HCC and GBC groups, IL-2, IL-6, IL-10, and TNF-α in the cholangiocellular carcinoma group, and IL-2, IL-6, IL-8, and TNF-α in the pancreatic cancer group.
Conclusion.
We suggest that cytokines can be used as useful markers in the diagnosis of HPB cancers.
American Psychological Association (APA)
Koca, Yavuz Savas& Bulbul, Mahmut& Barut, İbrahim. 2017. The Diagnostic Roles of Cytokines in Hepatobiliary Cancers. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1135614
Modern Language Association (MLA)
Koca, Yavuz Savas…[et al.]. The Diagnostic Roles of Cytokines in Hepatobiliary Cancers. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1135614
American Medical Association (AMA)
Koca, Yavuz Savas& Bulbul, Mahmut& Barut, İbrahim. The Diagnostic Roles of Cytokines in Hepatobiliary Cancers. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1135614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135614