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Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease
Joint Authors
Xie, Jingdun
Wang, Haitao
Lin, Ting
Bi, Bing-Tian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau).
However, the mechanisms underlying these neuropathological changes remain largely unclear.
To date, plenty of studies have shown that microglia-mediated neuroinflammation contributes to the pathogenesis of AD, and the microglia-synapse pathways have been repeatedly identified as the crucial factor in the disease process.
In this review, evidences from microglia and synapse studies are presented, and the role of microglia in the pathogenesis of AD, the contributing factors to synapse dysfunction, and the role and mechanisms of microglia-synapse pathways will be discussed.
American Psychological Association (APA)
Xie, Jingdun& Wang, Haitao& Lin, Ting& Bi, Bing-Tian. 2017. Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135626
Modern Language Association (MLA)
Xie, Jingdun…[et al.]. Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1135626
American Medical Association (AMA)
Xie, Jingdun& Wang, Haitao& Lin, Ting& Bi, Bing-Tian. Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135626