Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais
Joint Authors
Pôrto, Luiz Alberto Bomjardim
Grossi, Maria Aparecida de Faria
Alecrim, Edilamar Silva de
Xavier, Marcus Henrique de Souza Brito
Paiva e Silva, Frederico
Pires, Amalia Sathler
Silva, Fabianny Sanglard da
Lyon, Sandra
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Erythema nodosum leprosum (ENL) is a type of lepra reaction treated with corticosteroids and thalidomide, but this association increases the risk of deep venous thrombosis (DVT).
Objective.
To report cases of ENL with DVT in the use of thalidomide/corticosteroid associated.
Methodology.
The study was conducted between December 2015 and December 2016 at the Eduardo de Menezes Hospital (HEM-FHEMIG).
Results.
A clinical case series of 16 patients, eight from HEM-FHEMIG and eight from the literature.
DVT occurred on 4 continents, mainly in adults and men.
All patients were multibacillary; four people had pulmonary embolism (PE); there were 11 unilateral and five bilateral DVT cases; 12 cases were proximal, two distal, and two unspecified.
Pharmacological thromboprophylaxis was used on two individuals.
Outcome after DVT, 14 patients improved, one had sequelae, and one died.
Discussion.
DVT increased in association with thalidomide/corticosteroid in multiple myeloma, but this complication is poorly described in ENL.
In proximal DVT, there was a greater risk of PE and sequelae venous insufficiency.
After DVT, start anticoagulation.
ASA 100mg/day as prophylaxis for DVT in case of this drug association in ENL is recommended.
Conclusion.
The article illustrates the incidence increase of DVT because of the thalidomide/corticosteroid combination in ENL.
When this association is necessary, use ASA 100mg/day as prophylaxis.
American Psychological Association (APA)
Pôrto, Luiz Alberto Bomjardim& Grossi, Maria Aparecida de Faria& Alecrim, Edilamar Silva de& Xavier, Marcus Henrique de Souza Brito& Paiva e Silva, Frederico& Pires, Amalia Sathler…[et al.]. 2019. Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais. Case Reports in Dermatological Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135632
Modern Language Association (MLA)
Pôrto, Luiz Alberto Bomjardim…[et al.]. Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais. Case Reports in Dermatological Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1135632
American Medical Association (AMA)
Pôrto, Luiz Alberto Bomjardim& Grossi, Maria Aparecida de Faria& Alecrim, Edilamar Silva de& Xavier, Marcus Henrique de Souza Brito& Paiva e Silva, Frederico& Pires, Amalia Sathler…[et al.]. Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais. Case Reports in Dermatological Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135632