KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han
Joint Authors
Zhen, Jian Xin
Cai, Si Qi
Chen, Yuan Tao
Yang, Zhi Chao
Zhuo, Jia Cai
Deng, Zhi Hui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The association studies of killer cell immunoglobulin-like receptors (KIRs) with the occurrence of myelodysplastic syndromes (MDS) are limited worldwide; this study investigated the genetic risk/protective factors of MDS in KIR and human leucocyte antigen (HLA) systems to gain a better understanding of the role played by KIR and their cognate HLA ligands in MDS pathogenesis.
Methods.
We genotyped a total number of 77 patients with MDS from Chinese Southern Han and 745 healthy controls for the KIR loci and HLA class I.
The carrier frequencies of KIR genes, KIR genotypes, class I HLA ligands, and KIR-HLA combinations were calculated by direct counting.
The effect of individual KIR genes and HLA ligands on MDS risk was evaluated by logistic regression analyses using SAS 9.2 software.
Results.
We found that neither the KIR genes nor the KIR genotypes were associated with the occurrence of MDS.
However, we observed that the frequencies for the strong inhibitory ligand HLA-Bw4 as well as KIR3DL1-HLA-Bw4 combination were significantly higher in healthy controls than those in the MDS patient group, respectively (73.42% vs.
62.34%, P=0.038; 70.87% vs.
59.74%, P=0.043).
Conclusion.
Our results showed that HLA-Bw4 ligand and KIR3DL1-HLA-Bw4 combination could confer a protective effect against MDS in Chinese Southern Han.
American Psychological Association (APA)
Zhen, Jian Xin& Cai, Si Qi& Chen, Yuan Tao& Yang, Zhi Chao& Zhuo, Jia Cai& Deng, Zhi Hui. 2020. KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135644
Modern Language Association (MLA)
Zhen, Jian Xin…[et al.]. KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1135644
American Medical Association (AMA)
Zhen, Jian Xin& Cai, Si Qi& Chen, Yuan Tao& Yang, Zhi Chao& Zhuo, Jia Cai& Deng, Zhi Hui. KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1135644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135644