Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis
Joint Authors
Feng, Shiqing
Wang, Hongbo
Liu, Binfeng
Li, Ang
Wang, Jialin
Zhai, Gongwei
Ma, Haohao
Liu, Liyun
Gao, Yanzheng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Corneal wound healing results in the formation of opaque corneal scar.
In fact, millions of people around the world suffer from corneal scars, leading to loss of vision.
This study aimed to identify the key changes of gene expression in the formation of opaque corneal scar and provided potential biomarker candidates for clinical treatment and drug target discovery.
We downloaded Gene expression dataset GSE6676 from NCBI-GEO, and analyzed the Differentially Expressed Genes (DEGs), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway analyses, and protein-protein interaction (PPI) network.
A total of 1377 differentially expressed genes were identified and the result of Functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) identification and protein-protein interaction (PPI) networks were performed.
In total, 7 hub genes IL6 (interleukin-6), MMP9 (matrix metallopeptidase 9), CXCL10 (C-X-C motif chemokine ligand 10), MAPK8 (mitogen-activated protein kinase 8), TLR4 (toll-like receptor 4), HGF (hepatocyte growth factor), EDN1 (endothelin 1) were selected.
In conclusion, the DEGS, Hub genes and signal pathways identified in this study can help us understand the molecular mechanism of corneal scar formation and provide candidate targets for the diagnosis and treatment of corneal scar.
American Psychological Association (APA)
Liu, Binfeng& Li, Ang& Wang, Hongbo& Wang, Jialin& Zhai, Gongwei& Ma, Haohao…[et al.]. 2020. Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135665
Modern Language Association (MLA)
Liu, Binfeng…[et al.]. Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1135665
American Medical Association (AMA)
Liu, Binfeng& Li, Ang& Wang, Hongbo& Wang, Jialin& Zhai, Gongwei& Ma, Haohao…[et al.]. Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135665