PmDNE: Prediction of miRNA-Disease Association Based on Network Embedding and Network Similarity Analysis
Joint Authors
Zhang, Zhongqing
Li, Junyi
Liu, Ying
Wang, Yadong
Liu, Bo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Successful prediction of miRNA-disease association is nontrivial for the diagnosis and prognosis of genetic diseases.
There are many methods to predict miRNA and disease, but biological data are numerous and complex, and they often exist in the form of network.
How to accurately use the features of miRNA and disease-related biological networks to predict unknown association has always been a challenge.
Here, we propose PmDNE, a method based on network embedding and network similarity analysis, to predict the miRNA-disease association.
In PmDNE, the structure of network bipartite graph is improved, and a random walk generator is designed.
For embedded vectors, 128 dimensions are used, and the accuracy of prediction is significantly improved.
Compared with other network embedding methods, PmDNE is comparable and competitive with the state of art methods.
Our method can solve the problem of feature extraction, reduce the dimension of features, and improve the efficiency of miRNA-disease association prediction.
This method can also be extended to other area for biomedical network prediction.
American Psychological Association (APA)
Li, Junyi& Liu, Ying& Zhang, Zhongqing& Liu, Bo& Wang, Yadong. 2020. PmDNE: Prediction of miRNA-Disease Association Based on Network Embedding and Network Similarity Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135674
Modern Language Association (MLA)
Li, Junyi…[et al.]. PmDNE: Prediction of miRNA-Disease Association Based on Network Embedding and Network Similarity Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1135674
American Medical Association (AMA)
Li, Junyi& Liu, Ying& Zhang, Zhongqing& Liu, Bo& Wang, Yadong. PmDNE: Prediction of miRNA-Disease Association Based on Network Embedding and Network Similarity Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135674