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Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis
Joint Authors
Vigouroux, Corinne
Idbaih, Ahmed
Andreelli, Fabrizio
Sollier, Mathilde
Halbron, Marine
Donadieu, Jean
Cohen Aubart, Fleur
Auclair, Martine
Bourron, Olivier
Bastin, Marie
Béra, Géraldine
Touraine, Philippe
Young, Jacques
Mosbah, Héléna
Hartemann, Agnès
Amouyal, Chloé
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Langerhans Cell Histiocytosis (LCH) is a rare inflammatory neoplasm characterized by an infiltration of organs by Langerin + (CD207+) and CD1a+ histiocytes.
Diabetes insipidus is a frequent manifestation of the disease, while diabetes mellitus is very rare.
We report the first case of a 20-year-old man suffering from hypothalamopituitary histiocytosis and diabetes mellitus with serum anti-insulin receptor antibodies.
Case Presentation.
A 20-year-old patient was admitted for the evaluation of growth delay and hyperphagia.
HbA1c level and fasting blood glucose were in the normal range.
The diagnosis of hypothalamopituitary histiocytosis was based on histological features after biopsy of a large suprachiasmatic lesion identified on magnetic resonance imaging (MRI).
Association of vinblastine and purinethol was started followed by a second-line therapy by cladribine.
During the follow-up, the patient was admitted for recurrence of hyperglycemic states and extreme insulin resistance.
The screening for serum anti-insulin receptor antibodies was positive.
Each episode of hyperglycemia appeared to be correlated with tumoral activity and increase in serum anti-insulin receptor antibodies and appeared to be improved when the disease was controlled by chemotherapy.
Conclusion.
We report the first description of a hypothalamopituitary histiocytosis associated with serum anti-insulin receptor antibodies, extreme insulin resistance, and diabetes.
Parallel evolution of glucose levels and serum anti-insulin receptor antibodies seemed to be the consequence of immune suppressive properties of cladribine.
American Psychological Association (APA)
Sollier, Mathilde& Halbron, Marine& Donadieu, Jean& Idbaih, Ahmed& Cohen Aubart, Fleur& Vigouroux, Corinne…[et al.]. 2019. Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis. Case Reports in Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1135698
Modern Language Association (MLA)
Sollier, Mathilde…[et al.]. Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis. Case Reports in Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1135698
American Medical Association (AMA)
Sollier, Mathilde& Halbron, Marine& Donadieu, Jean& Idbaih, Ahmed& Cohen Aubart, Fleur& Vigouroux, Corinne…[et al.]. Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis. Case Reports in Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1135698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135698