Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews
Joint Authors
De Berardis, Domenico
Fornaro, Michele
Iasevoli, Felice
Carvalho, André Férrer
Köhler, Cristiano A.
Orsolini, Laura
Perna, Giampaolo
Solmi, Marco
Veronese, Nicola
Buonaguro, Elisabetta Filomena
de Bartolomeis, Andrea
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Introduction.
A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013.
While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic.
Methods.
Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception until October 2016.
Results.
Twelve included systematic reviews were of moderate-to-high quality and consistent in covering the handful of RCTs available to date, suggesting the promising efficacy, safety, and tolerability profile of lurasidone.
Concordance on the drug profile seems to be corroborated by a steadily increasing number of convergent qualitative reports on the matter.
Limitations.
Publication, sponsorship, language, citation, and measurement biases.
Conclusions.
Despite being preliminary in nature, this overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall.
As outlined by most of the reviewed evidence, recommendations for future research should include further controlled trials of extended duration.
American Psychological Association (APA)
Fornaro, Michele& De Berardis, Domenico& Perna, Giampaolo& Solmi, Marco& Veronese, Nicola& Orsolini, Laura…[et al.]. 2017. Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews. BioMed Research International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1135699
Modern Language Association (MLA)
Fornaro, Michele…[et al.]. Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews. BioMed Research International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1135699
American Medical Association (AMA)
Fornaro, Michele& De Berardis, Domenico& Perna, Giampaolo& Solmi, Marco& Veronese, Nicola& Orsolini, Laura…[et al.]. Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1135699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135699