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Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes
Joint Authors
Nie, Hua
Tang, Yunge
Qin, Weibing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This review analyses the genetic mechanisms of acephalic spermatozoa (AS) defects, which are associated with primary infertility in men.
Several target genes of headless sperms have been identified but intracytoplasmic sperm injection (ICSI) outcomes are complex.
Based on electron microscopic observations, broken points of the sperm neck are AS defects that are based on various genes that can be classified into three subtypes: HOOK1, SUN5, and PMFBP1 genes of subtype II; TSGA10 and BRDT genes of subgroup III, while the genetic mechanism(s) and aetiology of AS defects of subtype I have not been described and remain to be explored.
Interestingly, all AS sperm of subtype II achieved better ICSI outcomes than other subtypes, resulting in clinical pregnancies and live births.
For subtype III, the failure of clinical pregnancy can be explained by the defects of paternal centrioles that arrest embryonic development; for subtype I, this was due to a lack of a distal centriole.
Consequently, the embryo quality and potential ICSI results of AS defects can be predicted by the subtypes of AS defects.
However, this conclusion with regard to ICSI outcomes based on subtypes still needs further research, while the existence of quality of oocyte and implantation failure in women cannot be ignored.
American Psychological Association (APA)
Nie, Hua& Tang, Yunge& Qin, Weibing. 2020. Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135701
Modern Language Association (MLA)
Nie, Hua…[et al.]. Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1135701
American Medical Association (AMA)
Nie, Hua& Tang, Yunge& Qin, Weibing. Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135701