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Expression, Prognosis, and Immune Infiltrates Analyses of E2Fs in Human Brain and CNS Cancer
Joint Authors
Liao, Pan
Han, Shuzhen
Qu, Honglan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Objective.
We investigated the expression patterns, potential functions, unique prognostic value, and potential therapeutic targets of E2Fs in brain and CNS cancer and tumor-infiltrating immune cell microenvironments.
Methods.
We analyzed E2F mRNA expression levels in diverse cancer types via Oncomine and GEPIA databases, respectively.
Moreover, we evaluated the prognostic values using GEPIA database and TCGAportal database and the correlation of E2F expression with immune infiltration and the correlation between immune cell infiltration and GBM and LGG prognosis via TIMER database.
Then, cBioPortal, GeneMANIA, and DAVID databases were used for mutation analysis, PPI network analysis of coexpressed gene, and functional enrichment analysis.
Results.
E2F1-8 expression increased in most cancers, including brain and CNS cancer.
Higher expression in E2F1, 2, 4, 6, 7, and 8 indicated poor OS of LGG.
Higher E2F3–6 and E2F1–8 expressions correlated with poor prognosis and increased immune infiltration levels in CD8+ T cells, macrophages, neutrophils, and DCs in GBM and CD8+ T cells, B cells, CD4+ T cells, neutrophils, macrophages, and DCs in LGG, respectively.
Conclusion.
E2F1–8 and E2F2–8 could be hopeful prognostic biomarkers of GBM and LGG, respectively.
E2F3–6 and E2F1–8 could be likely therapeutic targets in patients with immune cell infiltration of GBM and LGG, respectively.
American Psychological Association (APA)
Liao, Pan& Han, Shuzhen& Qu, Honglan. 2020. Expression, Prognosis, and Immune Infiltrates Analyses of E2Fs in Human Brain and CNS Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1135704
Modern Language Association (MLA)
Liao, Pan…[et al.]. Expression, Prognosis, and Immune Infiltrates Analyses of E2Fs in Human Brain and CNS Cancer. BioMed Research International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1135704
American Medical Association (AMA)
Liao, Pan& Han, Shuzhen& Qu, Honglan. Expression, Prognosis, and Immune Infiltrates Analyses of E2Fs in Human Brain and CNS Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1135704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135704