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Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma
Joint Authors
Carvalho, D.
Freitas, P.
Fonseca, Elsa
Castro Oliveira, Sofia
Neves, João Sérgio
Souteiro, Pedro
Belo, Sandra
Oliveira, Ana Isabel
Moreira, Helena
Mergulhão Gomes, Paulo
Coelho, Lígia
Sarmento, Cristina
Neves, Celestino
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Adrenocorticotropic hormone (ACTH) ectopic production is a rare cause of Cushing syndrome (CS).
The most commonly associated tumours are small-cell lung carcinoma along with bronchial and thymic carcinoids.
To date, only 5 cases have been published in the literature featuring ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland.
We hereby describe a very uncommon case of ectopic CS (ECS) unveiling a metastatic parotid ACC.
Case Presentation.
A 46-year-old man with hypertension and dyslipidemia diagnosed 4-months before, as well as new-onset diabetes mellitus unveiled 1-month earlier, was referred to emergency department for hypokalemia.
Hormonal study and dynamic biochemical tests performed indicated ECS.
Imaging and cytological findings pointed toward a likely primary right parotid malignancy with liver metastases.
Somatostatin receptor scintigraphy has shown an increased uptake in the parotid gland and mild expression in liver metastasis.
The patient underwent right parotidectomy, and histopathologic examination confirmed ACC.
Meanwhile, hypercortisolism was managed with metyrapone, ketoconazole, and lanreotide.
Despite chemotherapy onset, a rapid disease progression and clinical course deterioration was observed.
Conclusion.
The present report highlights a rare ECS, exposing a metastatic parotid ACC, with an aggressive and challenging clinical course, representing the first case whose diagnosis of ECS came prior to ACC.
American Psychological Association (APA)
Castro Oliveira, Sofia& Neves, João Sérgio& Souteiro, Pedro& Belo, Sandra& Oliveira, Ana Isabel& Moreira, Helena…[et al.]. 2019. Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma. Case Reports in Endocrinology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135713
Modern Language Association (MLA)
Castro Oliveira, Sofia…[et al.]. Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma. Case Reports in Endocrinology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1135713
American Medical Association (AMA)
Castro Oliveira, Sofia& Neves, João Sérgio& Souteiro, Pedro& Belo, Sandra& Oliveira, Ana Isabel& Moreira, Helena…[et al.]. Ectopic Cushing’s Syndrome Unveiling a Metastatic Parotid Carcinoma. Case Reports in Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1135713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135713