Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats

Joint Authors

El Rabey, Haddad A.
Al-Seeni, Madeha N.
Al-Ghamdi, Habibah B.

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-09-28

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes.

The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats.

Twenty-four male albino rats were divided into four groups (n=6).

Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively.

The experiment was conducted for eight weeks.

The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL).

Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance.

It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues.

The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.

American Psychological Association (APA)

El Rabey, Haddad A.& Al-Seeni, Madeha N.& Al-Ghamdi, Habibah B.. 2017. Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135716

Modern Language Association (MLA)

El Rabey, Haddad A.…[et al.]. Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1135716

American Medical Association (AMA)

El Rabey, Haddad A.& Al-Seeni, Madeha N.& Al-Ghamdi, Habibah B.. Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135716

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1135716