Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases
Joint Authors
Chen, Meng
Zhou, Chong
Xia, Youyou
Huang, Pei
Guan, Luan
Shen, Xiaoming
Hao, Dawei
Ren, Hongrong
Lian, Lian
Yin, Haitao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To analyze retrospectively the clinical efficacy and safety for patients treated with fractionated stereotactic radiation therapy (FSRT) using volumetric modulated arc therapy.
Methods.
Between 2016 and 2017, 46 patients with solitary brain metastasis who underwent FSRT consisting of 25-40 Gy/5 fractions were recruited in this study.
All targets within the same course received different prescriptions according to size.
Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 4.0.
Results.
The median follow-up was 11 months (3-53 months).
The 6-month and 12-month local control rate calculated by Kaplan-Meier estimate was, respectively, 95% and 86%.
Tumor diameter<2.5 cm obtained 100% improved 12-month local control rate compared with 66% in those with ≥2.5 cm (P<0.001).
The 12-month local control calculated by Kaplan-Meier estimate was 95% in tumors with >30 Gy treatment and only 60% in tumors with ≤30 Gy treatment (P=0.001).
Multivariate analysis revealed that the prescription dose≤30 Gy resulted in increased local failure (hazard ratio (HR), 0.14 (range, 0.019-0.95; P=.046)).
Grade 3 or worse toxic effects were found in 5 (11%) patients, and no patient experienced surgical resection for symptomatic radioactive necrosis.
Conclusions.
FSRT for solid brain metastasis appears to have the advantages of a high rate of local control with a minimal risk of severe toxicity and deserves application in the clinical practice.
American Psychological Association (APA)
Zhou, Chong& Xia, Youyou& Huang, Pei& Guan, Luan& Shen, Xiaoming& Hao, Dawei…[et al.]. 2020. Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135741
Modern Language Association (MLA)
Zhou, Chong…[et al.]. Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1135741
American Medical Association (AMA)
Zhou, Chong& Xia, Youyou& Huang, Pei& Guan, Luan& Shen, Xiaoming& Hao, Dawei…[et al.]. Fractionated Stereotactic Radiation Therapy Using Volumetric Modulated Arc Therapy in Patients with Solitary Brain Metastases. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135741