White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations
Joint Authors
Tang, Yanqing
Zhou, Yifang
Liu, Jie
Driesen, Naomi
Womer, Fay
Chen, Kaiyuan
Wang, Ye
Jiang, Xiaowei
Zhou, Qian
Bai, Chuan
Wang, Dahai
Wang, Fei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ).
Understanding these variations may elucidate distinct markers of genetic vulnerability and conversion to psychosis.
To examine the similarities and differences in WM connectivity between those at-risk for and in early stages of SZ, a cross-sectional diffusion tensor imaging study of 48 individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic individuals at a high genetic risk of SZ (GHR-SZ), and 67 healthy controls (HC) was conducted.
Decreased fractional anisotropy (FA) in the corpus callosum (CC), anterior cingulum (AC), and uncinate fasciculus (UF) was observed in both the GHR-SZ and FE-SZ groups, while decreased FAs in the superior longitudinal fasciculus (SLF) and the fornix were only seen in the FE-SZ participants.
Additionally, both GHR-SZ and FE-SZ showed worse executive performance than HC.
The left SLF III FA was significantly positively correlated with hallucinations, and right SLF II was positively correlated with thought disorder.
The presence of shared WM deficits in both FE-SZ and GHR-SZ individuals may reflect the genetic liability to SZ, while the disparate FA changes in the FE-SZ group may represent symptom-generating circuitry that mediates perceptual and cognitive disturbances of SZ and ultimately culminates in the onset of psychotic episodes.
American Psychological Association (APA)
Zhou, Yifang& Liu, Jie& Driesen, Naomi& Womer, Fay& Chen, Kaiyuan& Wang, Ye…[et al.]. 2017. White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135750
Modern Language Association (MLA)
Zhou, Yifang…[et al.]. White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1135750
American Medical Association (AMA)
Zhou, Yifang& Liu, Jie& Driesen, Naomi& Womer, Fay& Chen, Kaiyuan& Wang, Ye…[et al.]. White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135750