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Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes
Joint Authors
Dry, Sarah M.
Nomoto, Hiroshi
Gurlo, Tatyana
Rosenberger, Madeline
Butler, Peter C.
Girgis, Mark D.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is unexplained deficit in size and function of the exocrine pancreas in type 1 diabetes (T1D).
We obtained pancreas from an individual with pre-T1D obtained at surgery and addressed the question, what is the relative inflammation in the exocrine and endocrine pancreas in pre-T1D in the absence of the potential confounding changes at autopsy or in brain dead organ donors.
Pancreas was removed surgically from a 36 year woman for benign neuroendocrine tumors (NET).
The patient had gestational diabetes at age 29 and has a 23 year old sister with T1D.
Pre-operative fasting glucose of 109 mg/dl and HbA1C 5.8% revealed prediabetes with an anti-GAD 1,144 (5–250 U/ml) together with family history implying pre-T1D.
There was patchy low grade immune infiltration in some, but not all, islets that met criteria for autoimmune insulitis.
The exocrine pancreas showed more abundant inflammation with areas of chronic pancreatitis and acinar to ductal metaplasia, and with other areas of atrophy and fatty infiltration.
In pre-T1D inflammation may be more prominent in the exocrine than the endocrine pancreas, calling into question the sequence of events and assumed islet centric basis of autoimmunity leading to T1D.
American Psychological Association (APA)
Nomoto, Hiroshi& Gurlo, Tatyana& Rosenberger, Madeline& Girgis, Mark D.& Dry, Sarah M.& Butler, Peter C.. 2019. Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Reports in Endocrinology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1135767
Modern Language Association (MLA)
Nomoto, Hiroshi…[et al.]. Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Reports in Endocrinology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1135767
American Medical Association (AMA)
Nomoto, Hiroshi& Gurlo, Tatyana& Rosenberger, Madeline& Girgis, Mark D.& Dry, Sarah M.& Butler, Peter C.. Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Reports in Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1135767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135767