Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus
Joint Authors
Fan, Yu
Jin, Jie
Zhang, Qian
Luo, Cheng
Xu, Ben
Yu, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
To evaluate the prognostic significance of preoperative gamma-glutamyltransferase (GGT) on the subgroup of nonmetastatic renal cell carcinoma (RCC) with venous tumor thrombus.
Materials and Methods.
We retrospectively reviewed the institutional database and collected the medical data of 156 patients with nonmetastatic RCC with venous tumor thrombus between March 2004 and December 2014.
Kaplan-Meier and Cox regression analyses were applied to determine the prognostic factors for cancer-specific survival (CSS) and recurrence-free survival (RFS).
Results.
The median value and optimal cutoff point of preoperative GGT were 23.0 and 37.5 IU/L, respectively.
In the entire cohort, 67 (42.9%) patients experienced disease recurrence, and 46 (29.5%) patients died.
Kaplan-Meier analysis revealed that the CSS and RFS rates were lower in patients with preoperative GGT ≥ 37.5 IU/L than in those with preoperative GGT < 37.5 IU/L.
Multivariate Cox proportional hazard analysis demonstrated that high preoperative GGT was significantly associated with shorter CSS (hazard ratio [HR]: 2.115; 95% CI: 1.164–3.843; p=0.014) and RFS (HR: 1.955; 95% CI: 1.166–3.276; p=0.011), after adjusting other covariates.
Conclusions.
Preoperative GGT can serve as an independent prognostic biomarker of nonmetastatic RCC patients with venous tumor thrombus.
Further prospective study is warranted to confirm our results.
American Psychological Association (APA)
Luo, Cheng& Xu, Ben& Fan, Yu& Yu, Wei& Zhang, Qian& Jin, Jie. 2017. Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135774
Modern Language Association (MLA)
Xu, Ben…[et al.]. Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135774
American Medical Association (AMA)
Luo, Cheng& Xu, Ben& Fan, Yu& Yu, Wei& Zhang, Qian& Jin, Jie. Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135774