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Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury
Joint Authors
Xie, Nianlin
Huan, Menglei
Tian, Feng
Gu, Zhongping
Li, Xiaofei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
As acute lung injury (ALI) caused high mortality rate, it is important to explore the protection and treatment of ALI.
The aim of the current study is to evaluate the effect of low molecular weight heparin (LMWH) nebulization on attenuating acute lung injury and the associated mechanism.
Methods.
The arterial blood gas, total protein content in bronchoalveolar lavage fluid, lung wet/dry weight ratio, malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and Akt phosphorylation were evaluated after the ALI rabbits were treated with or without LMWH nebulization.
Results.
PaO2 was increased and lung wet/dry weight ratio as well as total protein content in BALF was decreased after LMWH nebulization.
After the application of LMWH nebulization therapy, the SOD and GSH-Px activity was rebounded and the increase of MDA content was significantly inhibited.
The Akt protein phosphorylation level was decreased after LMWH nebulization therapy.
Conclusions.
LMWH nebulization treatment can relieve the traumatic ALI in rabbits and inhibit oxidative stress possibly by suppressing the Akt phosphorylation.
American Psychological Association (APA)
Xie, Nianlin& Huan, Menglei& Tian, Feng& Gu, Zhongping& Li, Xiaofei. 2017. Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1135789
Modern Language Association (MLA)
Xie, Nianlin…[et al.]. Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1135789
American Medical Association (AMA)
Xie, Nianlin& Huan, Menglei& Tian, Feng& Gu, Zhongping& Li, Xiaofei. Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1135789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135789