Biochemical and Clinical Features of Insulinoma in a Patient with Turner Syndrome
Joint Authors
Schneider, Darius A.
Zare, M.
Behnia, F.
Matesan, M.
Tylee, T.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Turner syndrome (TS), i.e., mosaic or nonmosaic states with only one normal X chromosome in females, is characterized by a wide spectrum of somatic, hormonal, and metabolic features.
Here we report an unusual case of recurrent hypoglycemia in a 53-year-old woman with TS.
Biochemical work-up following a 72h fast revealed detectable, inappropriate for low glucose insulin levels and elevated proinsulin and beta-hydroxybutyrate (BOHB) levels.
MR and multiphase CT showed a solid 2.5 cm pancreatic tail mass with absent uptake in the 111In-pentetreotide (Octreoscan) scan.
Subsequent hepatic vein blood sampling after intra-arterial calcium stimulation showed sharp increase in insulin and modest increase in proinsulin levels.
The patient underwent excision of the mass with resolution of symptoms.
Histopathologic examination confirmed the neuroendocrine etiology of the tumor.
This is, to our knowledge, the third report of TS and concomitant insulinoma.
Impaired counterregulatory response to hypoglycemia in patients with TS may result in symptomatic hypoglycemia with only mild insulin elevation and elevated proinsulin in setting of hypoglycemia may be the only indication of insulinoma in these patients.
BOHB levels should not be used for ruling out EHH in patients with TS.
American Psychological Association (APA)
Schneider, Darius A.& Zare, M.& Behnia, F.& Matesan, M.& Tylee, T.. 2019. Biochemical and Clinical Features of Insulinoma in a Patient with Turner Syndrome. Case Reports in Endocrinology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1135793
Modern Language Association (MLA)
Schneider, Darius A.…[et al.]. Biochemical and Clinical Features of Insulinoma in a Patient with Turner Syndrome. Case Reports in Endocrinology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1135793
American Medical Association (AMA)
Schneider, Darius A.& Zare, M.& Behnia, F.& Matesan, M.& Tylee, T.. Biochemical and Clinical Features of Insulinoma in a Patient with Turner Syndrome. Case Reports in Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1135793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135793