Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma
Joint Authors
Jiang, Kexin
He, Yijiang
Zhang, Xu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Esophageal squamous cell carcinoma (ESCC) is a leading malignancy with both high incidence and mortality worldwide.
However, the molecular mechanisms of the poor prognosis in ESCC are still unclear.
Methods.
We conducted differential expression analysis between ESCC and normal tissues and between ESCC samples with and without CNAs in a given gene.
Overrepresentation enrichment and gene set enrichment analyses were used to identify the oncogenic pathways and abnormal transcription factors (TFs).
The survival analysis was employed to identify the genes associated with overall survival.
Results.
In this study, we aimed to identify and interpret the driver genes triggered by the copy number alterations (CNAs), including CCND1, TEAD4, EIF4EBP1, EGFR, FGFR3, and FZD6.
Furthermore, we identified oncogenic pathways, including RTK-RAS, WNT, PI3K, Hippo, and cell cycle, and key TFs including TEAD4, a transcription factor in the Hippo signaling pathway, and LEF1 in the WNT signaling pathway.
Furthermore, we observed that upregulations of FGFR3 and EIF4EBP1 were significantly associated with shorter overall survival in ESCC.
Conclusion.
In conclusion, the driver genes triggered by CNAs not only exhibited critical functionality but also were clinically relevant in ESCC, which greatly improved our understanding of the molecular mechanisms in ESCC.
American Psychological Association (APA)
Jiang, Kexin& He, Yijiang& Zhang, Xu. 2020. Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135813
Modern Language Association (MLA)
Jiang, Kexin…[et al.]. Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1135813
American Medical Association (AMA)
Jiang, Kexin& He, Yijiang& Zhang, Xu. Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135813