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Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma
Joint Authors
Liu, Yi
Li, Rong-Hua
Ren, Gang
Jiang, Jin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Oral carcinoma is the sixth most common cancer and is a serious public health problem, and tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma.
Kinesin family member 22 (KIF22), also called as kinesin-like DNA binding protein (KID), is a microtubule-based motor protein and binds to both microtubules and chromosomes, transporting organelles, protein, and mRNA.
This research aimed at investigating the prognostic significance of KIF22 in TSCC.
Patients and Methods.
This retrospective research collected 82 paired tissues with TSCC.
KIF22 protein expression level was detected by immunohistochemical staining.
Suppression of KIF22 with shRNA in CAL-27 and SCC-15 cells was to observe cell proliferation in vitro and xenograft tumor growth in vivo.
Results.
In TSCC tissues, the protein expression level of KIF22 was increased and correlated with tumor stage, clinical stage, and lymphatic metastasis (P=0.013, P=0.034 and P=0.015, respectively).
Suppression of KIF22 inhibited cell proliferation and xenograft tumor growth.
Conclusion.
KIF22 might play an important role in the progression of TSCC and could serve as a therapeutic target for TSCC.
American Psychological Association (APA)
Liu, Yi& Li, Rong-Hua& Ren, Gang& Jiang, Jin. 2020. Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135815
Modern Language Association (MLA)
Liu, Yi…[et al.]. Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1135815
American Medical Association (AMA)
Liu, Yi& Li, Rong-Hua& Ren, Gang& Jiang, Jin. Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1135815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135815