Genotypic Diversity of Mycobacterium tuberculosis Clinical Isolates in the Multiethnic Area of the Xinjiang Uygur Autonomous Region in China
Joint Authors
Liu, Haican
Lian, Lulu
Zhao, Xiuqin
Yu, Qin
Liu, Jiao
Lu, Bing
Liu, Jie
Li, Junlian
Zhang, Jingrui
Qi, Yingcheng
Wan, Kanglin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
We studied the genetic diversity of clinical isolates from patients with tuberculosis in the multiethnic area of Xinjiang autonomous region in China.
A total of 311 clinical M.
tuberculosis isolates were collected in 2006 and 2011 and genotyped by two genotyping methods.
All isolates were grouped into 68 distinct spoligotypes using the spoligotyping method.
The Beijing family was dominant, followed by T1 and CAS.
MIRU-VNTR results showed that a total of 195 different VNTR types were identified.
Ten of the 15 loci were highly or moderately discriminant according to their HGDI scores, and 13 loci had good discriminatory power in non-Beijing family strains, whereas only two loci had good discriminatory power in Beijing family strains.
Chi-square tests demonstrated that there were no correlations between four characteristics (sex, age, type of case, and treatment history) and the Beijing family.
In summary, Beijing family strains were predominant in Xinjiang, and the VNTR-15China locus-set was suitable for genotyping all Xinjiang strains, but not for the Beijing family strains.
Thus, these data suggested that different genotype distributions may exist in different regions; MLVA locus-sets should be adjusted accordingly, with newly added loci to increase resolution if necessary.
American Psychological Association (APA)
Liu, Jie& Li, Junlian& Liu, Jiao& Zhao, Xiuqin& Lian, Lulu& Liu, Haican…[et al.]. 2017. Genotypic Diversity of Mycobacterium tuberculosis Clinical Isolates in the Multiethnic Area of the Xinjiang Uygur Autonomous Region in China. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135821
Modern Language Association (MLA)
Liu, Jie…[et al.]. Genotypic Diversity of Mycobacterium tuberculosis Clinical Isolates in the Multiethnic Area of the Xinjiang Uygur Autonomous Region in China. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1135821
American Medical Association (AMA)
Liu, Jie& Li, Junlian& Liu, Jiao& Zhao, Xiuqin& Lian, Lulu& Liu, Haican…[et al.]. Genotypic Diversity of Mycobacterium tuberculosis Clinical Isolates in the Multiethnic Area of the Xinjiang Uygur Autonomous Region in China. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135821