The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment
Joint Authors
Chojnacki, Jan
Błońska, Aleksandra
Chojnacki, Cezary
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Taking statins can cause increase in the level of aspartate and alanine aminotransferase.
The aim of this study was to assess the usefulness of melatonin in counteracting the adverse hepatic events from statins.
Methods.
The research program included 60 patients (aged 47–65 years, 41 women and 19 men) with hyperlipidemia taking atorvastatin or rosuvastatin at a dose of 20–40 mg daily.
The patients were randomly allocated in two groups.
Group I (n=30) was recommended to take the same statin at a standardized daily dose of 20 mg together with melatonin at a dose of 2×5 mg.
Group II (n=30) patients took statin with placebo at the same dose and time of the day.
Follow-up laboratory tests (AST, ALT, GGT, and ALP) were evaluated after 2, 4, and 6 months of treatment.
Results.
In Group I the levels of all enzymes decreased after 6 months, particularly AST, 97,2±19,1 U/L versus 52,8±12,3 U/L (p<0,001); ALT, 87,4±15,6 U/L versus 49,8±14,5 U/L (p<0,001); and GGT, 84,1±14,8 U/L versus 59,6 U/L (p<0,001).
Conclusion.
Melatonin exerts a hepatoprotective effect in patients taking statins.
American Psychological Association (APA)
Chojnacki, Cezary& Błońska, Aleksandra& Chojnacki, Jan. 2017. The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135837
Modern Language Association (MLA)
Chojnacki, Cezary…[et al.]. The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135837
American Medical Association (AMA)
Chojnacki, Cezary& Błońska, Aleksandra& Chojnacki, Jan. The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135837