Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats

Joint Authors

Li, Chun-Ying
Zhang, Lei
Li, Jing
Qi, Chun-Li
Li, Dong-Ying
Liu, Xu
Qu, Xian

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-11-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

The hippocampus is a key structure for encoding and processing memory and for spatial orientation, which are among the cognitive functions most sensitive to cerebral ischemia, hypoxia, and vascular dementia (VD).

Since hippocampal formation is one of the principle forebrain targets for arginine-vasopressin (AVP) innervations arising in the hypothalamic paraventricular nucleus (PVN), we explored the contributions of AVP to VD pathogenesis.

To this end, we randomly assigned pathogen-free, male Wistar rats to one of seven groups in a VD model and tested AVP treatment effects on spatial learning and memory using the Morris water maze.

We also measured the superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration in brain samples and monitored the expression of AVP-positive neurons in the hippocampus by immunohistochemistry.

The VD model with repeated cerebral ischemia-reperfusion injury evoked impairment of cognitive function and reduced cerebral concentrations of the antioxidation markers.

Lesioning the rat PVN showed a similar effect on learning and memory and reduced antioxidation markers in the brain tissue.

However, AVP injection into the PVN improved cognitive performance in VD rats, while enhancing/rectifying the changes in antioxidation markers.

We conclude that our VD model may decrease AVP secretion in the PVN and subsequently reduce antioxidant capacity in the hippocampus, leading to impaired cognitive function.

American Psychological Association (APA)

Li, Chun-Ying& Zhang, Lei& Li, Jing& Qi, Chun-Li& Li, Dong-Ying& Liu, Xu…[et al.]. 2017. Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135846

Modern Language Association (MLA)

Li, Chun-Ying…[et al.]. Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1135846

American Medical Association (AMA)

Li, Chun-Ying& Zhang, Lei& Li, Jing& Qi, Chun-Li& Li, Dong-Ying& Liu, Xu…[et al.]. Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1135846

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1135846