Analysis of the Expression of Cell Division Cycle-Associated Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases
Joint Authors
Chen, Chongxiang
Chen, Siliang
Pang, Lanlan
Yan, Honghong
Luo, Ma
Zhao, Qingyu
Lai, Jielan
Li, Huan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Lung cancer (LC) has become the top cause responsible for cancer-related deaths.
Cell division cycle-associated (CDCA) genes exert an important role in the life process.
Dysregulation in the process of cell division may lead to malignancy.
Methods.
Transcriptional data on CDCA gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan–Meier Plotter databases.
Results.
CDCA1/2/3/4/5/7/8 expression levels were higher in lung adenocarcinoma tissues, and the CDCA1/2/3/4/5/6/7/8 expression levels were increased in squamous cell LC tissues compared with those in noncarcinoma lung tissues.
The expression levels of CDCA1/2/3/4/5/8 showed correlation with tumor classification.
The Kaplan–Meier Plotter database was employed to carry out survival analysis, indicating that increased CDCA1/2/3/4/5/6/7/8 expression levels were obviously related to poor overall survival (OS) and progression-free survival (PFS) (P<0.05).
Only LC patients with increased CDCA3/4/5/8 expression were significantly related to lower post-progression survival (PPS) (P<0.05).
The following processes were affected by CDCA genes’ alteration: R-HAS-2500257: resolution of sister chromatid cohesion; GO:0051301: cell division; CORUM: 1118: chromosomal passenger complex (CPC, including CDCA8, INCENP, AURKB, and BIRC5); CORUM: 127: NDC80 kinetochore complex; M129: the PID PLK1 pathway; and GO: 0007080: mitotic metaphase plate congression, all of which were remarkably modulated since the alterations affected CDCA genes.
Conclusions.
Upregulated CDCA genes’ expression levels in LC tissues probably play a crucial part in LC oncogenesis.
The upregulated CDCA genes’ expression levels are used as the potential prognostic markers to improve patient survival and the LC prognostic accuracy.
CDCA genes probably exert their functions in tumorigenesis through the PLK1 pathway.
American Psychological Association (APA)
Chen, Chongxiang& Chen, Siliang& Pang, Lanlan& Yan, Honghong& Luo, Ma& Zhao, Qingyu…[et al.]. 2020. Analysis of the Expression of Cell Division Cycle-Associated Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1135854
Modern Language Association (MLA)
Chen, Chongxiang…[et al.]. Analysis of the Expression of Cell Division Cycle-Associated Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1135854
American Medical Association (AMA)
Chen, Chongxiang& Chen, Siliang& Pang, Lanlan& Yan, Honghong& Luo, Ma& Zhao, Qingyu…[et al.]. Analysis of the Expression of Cell Division Cycle-Associated Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1135854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135854