Dramatic Response to First Line Single Agent Pembrolizumab in Anaplastic Thyroid Carcinoma

Joint Authors

Spalart, Valérie
Legius, Barbara
Segers, Kurt
Coolen, Johan
Maes, Brigitte
Decoster, Lynn

Source

Case Reports in Endocrinology

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-11-26

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Diseases

Abstract EN

Anaplastic thyroid carcinoma (ATC) is a deadly disease with very limited therapeutic options.

There is an urgent need for new and efficacious drugs.

Unfortunately accrual in clinical trials is problematic because of the rarity of the disease and often poor performance status at diagnosis.

Recently some data have emerged suggesting a role for immunotherapy in the treatment of ATC.

We describe the case of a 75-year-old patient with poor performance status and compromised airway and oesophagus at diagnosis, showing a rapid and dramatic response to first line single agent pembrolizumab.

Disease progression in the brain occurred 16 months after initial diagnosis.

At that time there was ongoing extracranial disease control.

American Psychological Association (APA)

Spalart, Valérie& Legius, Barbara& Segers, Kurt& Coolen, Johan& Maes, Brigitte& Decoster, Lynn. 2019. Dramatic Response to First Line Single Agent Pembrolizumab in Anaplastic Thyroid Carcinoma. Case Reports in Endocrinology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1135855

Modern Language Association (MLA)

Spalart, Valérie…[et al.]. Dramatic Response to First Line Single Agent Pembrolizumab in Anaplastic Thyroid Carcinoma. Case Reports in Endocrinology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1135855

American Medical Association (AMA)

Spalart, Valérie& Legius, Barbara& Segers, Kurt& Coolen, Johan& Maes, Brigitte& Decoster, Lynn. Dramatic Response to First Line Single Agent Pembrolizumab in Anaplastic Thyroid Carcinoma. Case Reports in Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1135855

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1135855