Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
Joint Authors
Olczyk, Krystyna
Kuźnik-Trocha, Kornelia
Jura-Półtorak, Agnieszka
Kotyla, Przemyslaw J.
Kotulska-Kucharz, Anna
Kucharz, Eugeniusz J.
Winsz-Szczotka, Katarzyna
Komosinska-Vassev, Katarzyna
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was to determine whether plasma levels of total glycosaminoglycans (GAGs), matrix metalloproteinases (MMPs) (MMP-3, MMP-10), and their tissue inhibitors (TIMPs) (TIMP-1, TIMP-2) as well as transforming growth factor β (TGF-β) differ in the patients with systemic sclerosis (SSc) in relation to the healthy subjects.
Plasma samples were obtained from 106 people (64 patients with SSc and 42 healthy individuals) and measured for MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-β levels using ELISA methods.
GAGs isolated from plasma samples were quantified using a hexuronic acid assay.
The plasma levels of total GAGs, TIMP-1, TIMP-2, and TGF-β were significantly higher, while MMP-3 was significantly decreased in SSc patients compared to the controls.
We have revealed a significant correlation between plasma GAGs and TGF-β (r=–0.47) and TIMP-2 (r=0.38), respectively.
The results of this study revealed that remodeling of the extracellular matrix, reflected by quantitative changes in plasma glycosaminoglycans, occurs during systemic sclerosis.
Thus, the alterations in GAG metabolism connected with SSc may lead to systemic changes in the properties of the connective tissue extracellular matrix.
American Psychological Association (APA)
Kuźnik-Trocha, Kornelia& Winsz-Szczotka, Katarzyna& Komosinska-Vassev, Katarzyna& Jura-Półtorak, Agnieszka& Kotulska-Kucharz, Anna& Kucharz, Eugeniusz J.…[et al.]. 2020. Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135862
Modern Language Association (MLA)
Kuźnik-Trocha, Kornelia…[et al.]. Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135862
American Medical Association (AMA)
Kuźnik-Trocha, Kornelia& Winsz-Szczotka, Katarzyna& Komosinska-Vassev, Katarzyna& Jura-Półtorak, Agnieszka& Kotulska-Kucharz, Anna& Kucharz, Eugeniusz J.…[et al.]. Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135862