Association between Body Mass Index and Reproductive Outcome in Women with Polycystic Ovary Syndrome Receiving IVFICSI-ET
Joint Authors
Zhou, Han
Zhang, Dan
Luo, Zhuoye
Yang, Aimin
Cui, Na
Hao, Guimin
Wang, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To examine the association between body mass index (BMI) and the outcome of in vitro fertilization or intracytoplasmic sperm injection embryo transfer- (IVF/ICSI-ET) assisted reproduction in women with polycystic ovary syndrome (PCOS) receiving the ultra-long agonist protocol.
Methods.
We retrospectively identified all women receiving IVF/ICSI-ET for the first time using the ultra-long protocol between January 2013 and January 2018 at our hospital.
Only women at ≤35 years of age receiving the first cycle were analyzed.
Results.
A total of 1782 women were included in the analysis: 42 were underweight, 742 were overweight, 198 were obese, and 800 were normal weight.
Gonadotropin dosage and duration were comparable between underweight and normal weight groups but were significantly higher/longer in overweight and obese groups (P<0.008).
The number of oocytes retrieved was significantly lower in overweight and obese groups than in the normal weight group (P<0.008).
The number of transferable embryos was significantly higher in normal weight group than overweight and obese groups (P<0.008).
Embryo implantation rate, clinical pregnancy rate, full-term birth rate, and live birth rate did not differ among the 4 groups.
The cycle cancellation rate was lower in the overweight and obese group than normal weight group (P<0.008).
The miscarriage rate was higher in the obese group than the normal weight group (P<0.008).
In multivariate logistic regression analysis, abnormal BMI was an independent risk for miscarriage (OR: 1.069, 95% CI 1.020, 1.122; P=0.006).
Conclusion.
Overweight and obesity are associated with poor outcomes in PCOS patients receiving ultra-long protocol.
Measures to reduce body weight should be encouraged in overweight and obese PCOS women at ≤35 years of age prior to assisted reproductive technology (ART).
American Psychological Association (APA)
Zhou, Han& Zhang, Dan& Luo, Zhuoye& Yang, Aimin& Cui, Na& Hao, Guimin…[et al.]. 2020. Association between Body Mass Index and Reproductive Outcome in Women with Polycystic Ovary Syndrome Receiving IVFICSI-ET. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135877
Modern Language Association (MLA)
Zhou, Han…[et al.]. Association between Body Mass Index and Reproductive Outcome in Women with Polycystic Ovary Syndrome Receiving IVFICSI-ET. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1135877
American Medical Association (AMA)
Zhou, Han& Zhang, Dan& Luo, Zhuoye& Yang, Aimin& Cui, Na& Hao, Guimin…[et al.]. Association between Body Mass Index and Reproductive Outcome in Women with Polycystic Ovary Syndrome Receiving IVFICSI-ET. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135877