Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
Joint Authors
Ma, Chao
Luo, Xuefeng
Mahan, Wuluhan
Tang, Yahui
Duan, Yun
Mao, Rui
Xie, Zengru
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Osseous cyst echinococcosis (CE) is an infectious disease that causes disability and deformity in patients, yet there is still no satisfactory treatment.
Focusing on the feasibility and prognosis of radiotherapy as an adjuvant or palliative treatment for osseous CE, this study investigated the outcome of Meriones meridianus with osseous CE after radiotherapy.
Methods.
The study utilized a comparison control group design with three groups of gerbils, and 240 osseous CE gerbils were randomly divided into control, 40Gy/5times, and 50Gy/5times groups.
Different doses of radiotherapy were given to the gerbils, and then, the effects of radiotherapy on gerbils and lesions were observed at 3 and 6 months after radiotherapy.
Statistical analysis was done using χ2 test, unpaired t-test, and one-way ANOVA.
Results.
Significant changes (P<0.05) were achieved between the three groups in terms of seven parameters at 3 and 6 months, including the number of dead gerbils and lesion sites with ulceration and infection, number of dead scolices, protein content, Ca2+ concentration, the maximum diameter of lesion site, and wet weight of cysts.
Except for the number of dead gerbils and lesion sites with ulceration and infection, all other parameters were observed a big difference between 3 months and 6 months in the 50Gy/5times group.
Conclusion.
Radiotherapy at a dose of 50 Gy has inhibitory and therapeutic effects on osseous CE in gerbils, and radiotherapy could probably be a treatment option for persistent or recurrent osseous CE.
American Psychological Association (APA)
Ma, Chao& Luo, Xuefeng& Mahan, Wuluhan& Tang, Yahui& Duan, Yun& Mao, Rui…[et al.]. 2020. Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135886
Modern Language Association (MLA)
Ma, Chao…[et al.]. Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135886
American Medical Association (AMA)
Ma, Chao& Luo, Xuefeng& Mahan, Wuluhan& Tang, Yahui& Duan, Yun& Mao, Rui…[et al.]. Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135886