Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine
Joint Authors
Dai, Guoliang
Zhang, Nongshan
Wu, Yiyun
Xing, Runlin
Xu, Bo
Wang, Peimin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Brucine is the active component in traditional Chinese medicine “Ma-Qian-Zi” (Strychnos nux-vomica Linn), with capabilities of analgesic, anti-inflammatory, anti-tumor and so on.
It is crucial how to break through the impact of cuticle skin which reduces the penetration of drugs to improve drug transmission rate.
The aim of this study is to improve the local drug concentration by using ultrasound.
We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under the influence of various acoustic parameters, including frequency, amplitude and irradiation time.
The transdermal conditions of yellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet spectrophotometry.
The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label and brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability.
The best ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine concentration increased to 2-3 times.
This work will provide supportive data on how the brucine is better used for transdermal drug delivery (TDD).
American Psychological Association (APA)
Zhang, Nongshan& Wu, Yiyun& Xing, Runlin& Xu, Bo& Dai, Guoliang& Wang, Peimin. 2017. Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135903
Modern Language Association (MLA)
Zhang, Nongshan…[et al.]. Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1135903
American Medical Association (AMA)
Zhang, Nongshan& Wu, Yiyun& Xing, Runlin& Xu, Bo& Dai, Guoliang& Wang, Peimin. Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1135903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135903